Klára Briknarová - Associate Professor
Office Location: CHEM 111 Office Telephone: (406) 243-4408 E-mail: klara.briknarova@umontana.edu |
Current Position:
Associate Professor, Department of Chemistry and Biochemistry
Description:
Klára Briknarová came to the University of Montana in November 2005. Klára received her undergraduate education from School of Mathematics and Physics at Charles University in Prague, Czech Republic. She carried out graduate studies in the laboratory of Professor Miguel Llinás at Carnegie Mellon University, and earned her PhD. in Biophysics/Chemistry in 1999. Klára then worked as a postdoctoral fellow in the laboratory of Professor Kathryn R. Ely at the Burnham Institute, and was promoted to Research Assistant Professor in 2005. Klára is a biochemist and structural biologist specializing in biomolecular nuclear magnetic resonance (NMR) spectroscopy.
Field Of Study:
Structural biology; biomolecular nuclear magnetic resonance (NMR) spectroscopy; protein structure, function and dynamics.
Research Interests:
We use nuclear magnetic resonance (NMR) spectroscopy, biochemical and biophysical techniques to study the structure, function and dynamics of biological macromolecules. Proteins of particular interest include components of the extracellular matrix, transcription factors and viral envelope glycoproteins.
Courses:
Autumn 2011 Physical Chemistry - Kinetics and Thermodynamics (CHMY 373)
Education:
M.S. in Biophysics and Chemical Physics, School of Mathematics and Physics, Charles University, Prague, Czech Republic, 1992
Ph.D. in Chemistry/Biophysics, Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, 1999
Selected Publications:
Thomas, C.J., Briknarová, K., Hilmer, J.K., Movahed, N., Bothner, B., Sumida, J.P., Tall, G.G. and Sprang, S.R. (2011). The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gai1. PLoS ONE 6, e23197.
Briknarová, K., Atwater, D.Z., Glicken, J.M., Maynard, S.J. and Ness, T.E. (2011). The PR/SET domain in PRDM4 is preceded by a zinc knuckle. Proteins 79, 2341-2345.
Briknarová, K., Thomas, C.J., York, J. and Nunberg, J.H. (2011). Structure of a zinc-binding domain in the Junín virus envelope glycoprotein. J. Biol. Chem. 286, 1528-1536.
Briknarová, K., Zhou, X., Satterthwait, A., Hoyt, D.W., Ely, K.R. and Huang, S. (2008). Structural studies of the SET domain from RIZ1 tumor suppressor. Biochem. Biophys. Res. Commun. 366, 807-813.
Briknarová, K., Nasertorabi, F., Havert, M.L., Eggleston, E., Hoyt, D.W., Li, C., Olson, A.J., Vuori, K. and Ely, K.R. (2005). The serine-rich domain from Crk-associated substrate (p130Cas) is a four-helix bundle. J. Biol. Chem. 280, 21908-21914
Derunes, C., Briknarová, K., Geng, L., Li, S., Gessner, C.R., Hewitt, K., Wu, S., Huang, S., Woods, V.I. Jr. and Ely, K.R. (2005). Characterization of the PR domain of RIZ1 histone methyltransferase. Biochem. Biophys. Res. Commun. 333, 925-934.
Briknarová, K., Åkerman, M.E., Hoyt, D.W., Ruoslahti, E. and Ely, K.R. (2003). Anastellin, an FN3 fragment with fibronectin polymerization activity, resembles amyloid fibril precursors. J. Mol. Biol. 332, 205-215.
Briknarová, K., Takayama, S., Homma, S., Baker, K., Cabezas, E., Hoyt, D.W., Li, Z., Satterthwait, A.C. and Ely, K.R. (2002). BAG4/SODD protein contains a short BAG domain. J. Biol. Chem. 277, 31172-31178.
Briknarová, K., Takayama, S., Brive, L., Havert, M.L., Knee, D.A., Velasco, J., Homma, S., Cabezas, E., Stuart, J., Hoyt, D.W., Satterthwait, A.C., Llinás, M., Reed, J.C. and Ely, K.R. (2001). Structural analysis of BAG1 co-chaperone and its interactions with Hsc70 heat shock protein. Nature Struct. Biol. 8, 349-352.